The first step in stem cell testing is to actually cultivate a mature stem cell in a lab dish. Once the researcher has the cell, he can determine whether the body can use it. Cells that produce insulin, for instance, are only useful to the body if they continue this function once they have been implanted. Thus, much time is spent figuring out whether cells will actually integrate with the surrounding tissues in the body.
Researchers need a model to test this viability, so they rely on animals that have a similar genetic makeup to our own. Experimentation on this level requires a painstaking attention to detail, and plenty of trial and error. A stem cell that is meant to restore spinal function to an animal may not cure the issue, but may allow the animal some control over its bladder. These benefits aren’t exactly what the researchers hoped for, but they can still benefit many patients. So there is a tradeoff of possible outcomes that scientists must be aware of.
In most of these cases, the results of a single test do not match actual use cases. Most of the animal models are “best guesses,” and may not fit the human scenario perfectly. This is most obvious in mice: where the same disease can exist in both humans and mice, but have very different outcomes. Researchers require many test cases in different animals to try and approximate the goals of treatment, or else the drugs won’t function properly when used in the real world.
Bio: Sasha Bakhru is a leading bio-medical researcher. As co-founder of NeuroBank, Sasha Bakhru is helping patients to store stem cells long-term for treatment.
Stem cells are like the blank slates of our bodies. At birth, and even before, our bodies are differentiating our cells and assigning them duties. In multi-cellular organisms like ourselves, our bodies are like great task masters. Once these cells have a job they stick to that duty, but anything goes until a cell is uniquely identified.
Stem cells were all the medical rage as recently as ten years ago, when scientist speculated they could apply these cells to various diseases. One of the worst offenders was cancer, and stem cells provided a ray of hope for cancer patients seeking alternative treatments.
This thinking is actually slightly flawed at the moment, as we don’t use stem cells to actually treat cancer, we use them to repair the damage that our cures do to the body. A patient’s body is rigorously treated to remove any and all cancer cells. This battery of radiation and chemo-therapy leaves our bodies feeling weakened and exhausted. Stem cells may be the solution for this.
Additionally, there appears to be stem cells that help form tumors. If we let these cells roam freely, cancer develops over time. Scientists now believe that by targeting these stem cells, we may actually inhibit cancers before they begin to metastasize in the body.
The wide ranging applications of this research will change cancer treatment in the future. Rather than trying to kill cells from the outside, we may see medical science pursue a new strategy that destroys cells from within.
Bio: The preceding guest post was brought to you by Sasha Bakhru. To learn more about stem cells, and other bio-medicine, visit Sasha Bakhru online.
The brain is a network of billions of neurons that send trillions of signals per second. More complex than any computer system man has engineered, the brain requires technology to figure out what is actually happening on a molecular level.
An MRI brain scan measures the tissue of the brain, but it is not the only method of measuring brain activity. Scientists also use electrodes to detect brain waves from the scalp. Magnets can also help measure pulses from the brain, or placed inside the brain to detect impulses. The results give researchers evidence of how the brain reacts, with images to reflect those assertions.
Middle-grade technology for brain scanning typically involves working inside the skull. ECoGs (electrocorticography) use electrodes applied directly to the exposed surface of the brain. These invasive procedures are often performed when a patient is already undergoing brain surgery. Experimental therapies also look at the brain’s response to certain visual cues (like a strobe light). By observing how the brain works, we can make assumptions about what parts of the brain are most affected by treatment.
Low-level technology studies brain tissue, and usually requires a biopsy. A microscope is used to take high-resolution photos of tissue for study. Fluorescent dyes are also used to highlight brain tissue and make observation easier.
Neuroscience uses technology extensively to document what happens in the brain. Advanced usage of electrodes and software give doctors the means to research new avenues for treatment of neurodegenerative diseases. As scientists discover new methods to measure this activity, treatments will become more effective.
Author Bio: This post was contributed by Sasha Bakhru. A leading bio-medical researcher, Sasha Bakhru has made contributions to drug delivery and drug monitoring that have impacted patient care.
Sasha Bakhru is a scientist to watch out for. Bakhru’s work has been gaining a lot of attention in the fields of science and biomedicine recently. Sasha Bakhru has a variety of positions in the scientific and medical communities. First and foremost, Bakhru works as an adjunct assistant professor of medical science at Brown University in Providence, Rhode Island. In addition to that, he completed a Postdoctoral Fellowship there.
Sasha Bakhru’s work is unique as is his motivation. Bakhru is attempting to make a difference in the world. Bakhru’s important work has been published in a variety of ways. He has written out eight patents, co-authored twenty publications, and he contributed one chapter to a book.
Bakhru has an impressive educational background. Bakhru completed his Bachelors of Science in the subject of Biomedical Engineering from Columbia University, an M.S.E. from John Hopkins University in Materials Science and a Ph.D. from CarnegieMellonUniversity in Biomedical Engineering.
Bakhru has been widely recognized for a few of his educational achievements. For example, in 2008, he won the Global MOOT Corp competition. In 2009, he won the “Entrepreneur of the Year” award from the Carnegie Mellon Tepper School of Business.
In addition to his educational and institutional work, Bakhru also plays an important role in the world of pharmaceuticals. Bakhru serves as the Vice President and the CTO of Perosphere Inc. He was also one of the co-founders. Perosphere Inc. is a specialty pharmaceuticals company that is attempting to radically upgrade drug delivery technology systems. Perosphere focuses on “rescue” drugs. This noteworthy organization already has thirty patents on their revolutionary products and ten pending patents.
Author bio: Guest post is provided by Sasha Bakhru who works in the fields of science and medicine, specifically pharmaceuticals and stem cell research. Check out his website for more information.
Author bio: Guest post is provided by Sasha Bakhru, a leading scientist in stem cell research. Check out his website for more information.
One scientist to take note of today is Sasha Bakhru. Bakhru is developing quite a reputation in the fields of science and medicine due to his groundbreaking research and contributions. Bakhru is serving these industries in multiple ways.
For starters, Sasha Bakhru helped found the specialty pharmaceuticals company called Perosphere Inc. Bakhru has played an integral role for this company. He works as the VP and the CTO. Perosphere Inc. is attempting to change entire pharmaceuticals industry. They are currently working to innovate and update drug designs as well as drug delivery technology. Perosphere is one of the leading names today in “rescue” drugs. They currently have patents and pending patents on their versatile products. Perosphere is extremely discriminating in the type of chemicals and therapeutics that it utilizes. They make sure to use the highest quality chemicals around.
Sasha Bakhru also serves as an adjunct assistant professor of medical science at Brown University in Providence, Rhode Island. Bakhru has studied both science and medicine at length. He graduated in graduate studies in the subject of engineering science with an emphasis in biomedical and mechanical engineering.
In addition to multiple jobs, Bakhru is continually engaged in various projects and types of research. He is working to design polymeric hydrogel-based scaffolds for ex vivo neural stem cell expansion. He has made many important contributions to the field of science such as engineering a microcapsule-based platform, capable of detecting the impact of various biochemical and topographical cues on both growth and diversity.
Sasha Bakhru is a VP, CTO, and Co-Founder at Perosphere Inc, a specialty pharmaceuticals company, and an adjunct assistant professor of medical science at Brown University in Providence, RI. Meaningful accomplishments that Sasha Bakhru has achieved consist of an undertaking created to craft a microcapsule-based platform for locating the consequences of various biochemical and topographical cues on expansion and variance. In addition, he has made use of a methylated collagen, set by esterification of tiny bits of the carboxylic acid groups of glutamic and aspartic acid deposits on native porcine collagen (polycationic), and synthetic terpolymer, poly(HEMA: MAA: MMA) (polyanionic) to generate microcapsules by complex coascrevation at the interface of drops of methylated collagen blends consisting of stem cell suspensions and receiving baths of terpolymer blends.
Sasha Bakhru is an engineering science grauduate scholar researching biomedical design and mechanical engineering. Sasha received an academic degree in materials science and engineering examining the principles of the design of elements, their assemblage and tissue manufacturing. Existing ventures incorporate the development of polymeric hydrogel-based scaffolds for ex vivo neural stem cell multiplication.
Sasha Bakhru has likewise employed his competence by encapsulating rat neutral stem cells to examine them and understand the result functionalized 3D microenvironments have on substrate-adherent, pluripotent cells. Seek out publications of his efforts that are soon ahead. He intends to investigate polymer-based drug delivery procedures, micro-total analysis methods, and microfluidics and biological microelectromechanical systems. He is a proficient machinist, having 250 hours logged in cleansed fabrication settings. He has u dealt with Mathlab 6.0, Mathematica, Alias Wavefront, Java and C.
Sasha Bakhru is a VP, CTO, and Co-Founder at Perosphere Inc, a specialty pharmaceuticals company, and an adjunct assistant professor of medical science at Brown University in Providence, RI. Sasha Bakhru is an engineering science grauduate scholar analyzing biomedical manufacturing and mechanical engineering. Sasha attained an academic degree in materials science and engineering investigating the foundations of the design of substances, their assemblage and tissue design. Existing activities incorporate the creation of polymeric hydrogel-based scaffolds for ex vivo neural stem cell development.
Sasha Bakhru has similarly employed his abilities by encapsulating rat neutral stem cells to research them and understand the influence functionalized 3D microenvironments have on substrate-adherent, pluripotent cells. Watch out for publications of his efforts that are soon ahead. He intends to explore polymer-based drug delivery applications, micro-total analysis techniques, and microfluidics and biological microelectromechanical systems. He is a proficient machinist, having 250 hours logged in cleansed fabrication settings. He has u dealt with Mathlab 6.0, Mathematica, Alias Wavefront, Java and C.
Valuable successes that Sasha Bakhru has executed involve an undertaking created to craft a microcapsule-based platform for finding the consequences of distinct biochemical and topographical cues on development and variety. In addition, he has utilized a methylated collagen, set by esterification of tiny bits of the carboxylic acid groups of glutamic and aspartic acid deposits on native porcine collagen (polycationic), and synthetic terpolymer, poly(HEMA: MAA: MMA) (polyanionic) to make microcapsules by varied coascrevation at the interface of drops of methylated collagen blends including stem cell suspensions and receiving baths of terpolymer blends.